Interaction of Periplasmic Fab Production and Intracellular Redox Balance in Escherichia coli Affects Product Yield

Author:

Vazulka Sophie1,Schiavinato Matteo2,Wagenknecht Martin3,Cserjan-Puschmann Monika1ORCID,Striedner Gerald1

Affiliation:

1. Christian Doppler Laboratory for Production of Next-Level Biopharmaceuticals in E. Coli, Department of Biotechnology, Institute of Bioprocess Science and Engineering, University of Natural Resources and Life Sciences, Vienna, Muthgasse 18, 1190 Vienna, Austria

2. Department of Biotechnology, Institute of Computational Biology, University of Natural Resources and Life Sciences, Vienna, Muthgasse 18, 1190 Vienna, Austria

3. Boehringer Ingelheim RCV GmbH & Co KG, Dr.-Boehringer-Gasse 5-11, 1120 Vienna, Austria

Funder

Christian Doppler Forschungsgesellschaft

Bundesministerium f?r Digitalisierung und Wirtschaftsstandort

Rat f?r Forschung und Technologieentwicklung

Boehringer Ingelheim RCV GmbH and Co KG

Publisher

American Chemical Society (ACS)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Biomedical Engineering,General Medicine

Reference103 articles.

1. Ecker, D. M.; Crawford, T. J.; Seymour, P. The Therapeutic Monoclonal Antibody Product Market. BioProcess International, 2020, No. October 2020 Featured Report.

2. The Increasingly Human and Profitable Monoclonal Antibody Market

3. Microbials for the production of monoclonal antibodies and antibody fragments

4. How antibodies fold

5. Microbial platform technology for recombinant antibody fragment production: A review

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