Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor-Reference-Cited by-同舟云学术

Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor

Published:2012-08-23 Issue:9 Volume:3 Page:754-758
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Nakamura Yuji¹,Fujimoto Teppei¹,Ogawa Yasuyuki¹,Sugita Chie¹,Miyazaki Shojiro¹,Tamaki Kazuhiko¹,Takahashi Mizuki¹,Matsui Yumi¹,Nagayama Takahiro¹,Manabe Kenichi¹,Mizuno Makoto¹,Masubuchi Noriko¹,Chiba Katsuyoshi¹,Nishi Takahide¹

Affiliation:

1. Lead Discovery & Optimization Research Laboratories I, ‡Lead Discovery & Optimization Research Laboratories II, §Cardiovascular-Metabolics Research Laboratories, ∥Biological Research Laboratories, ⊥Drug Metabolism & Pharmacokinetics Research Laboratories, and #Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml300168e

Reference25 articles.

1. Drugs targeting the renin–angiotensin–aldosterone system

2. Renin-angiotensin system and cardiovascular risk

3. The role of renin-angiotensin-aldosterone system in the progression of chronic kidney disease

4. Angiotensin II: a key factor in the inflammatory and fibrotic response in kidney diseases

5. Clinical Experience With the Angiotensin II Receptor Antagonist Losartan

Cited by 16 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Theoretical investigation on known renin inhibitors and generation of ligand-based pharmacophore models for hypertension treatment;Journal of Biomolecular Structure and Dynamics;2023-10-28

2. Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor;Journal of Medicinal Chemistry;2022-08-08

3. Targeting renin receptor for the inhibition of renin angiotensin aldosterone system: An alternative approach through in silico drug discovery;Computational and Theoretical Chemistry;2022-02

4. Industrial Applications of Asymmetric Oxidations;Reference Module in Chemistry, Molecular Sciences and Chemical Engineering;2022

5. Adamantane-Substituted Purines and Their β-Cyclodextrin Complexes: Synthesis and Biological Activity;International Journal of Molecular Sciences;2021-11-24