Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors

Published:2014-10-28 Issue:1 Volume:6 Page:63-67
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Xu Yong¹,Brenning Benjamin G.¹,Kultgen Steven G.¹,Foulks Jason M.¹,Clifford Adrianne¹,Lai Shuping¹,Chan Ashley¹,Merx Shannon¹,McCullar Michael V.¹,Kanner Steven B.¹,Ho Koc-Kan¹

Affiliation:

1. Astex Pharmaceuticals, Inc., 4140 Dublin Boulevard, Suite 200, Dublin, California 94568 United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml500300c

Reference25 articles.

1. Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region

2. Mice Deficient for All PIM Kinases Display Reduced Body Size and Impaired Responses to Hematopoietic Growth Factors

3. Fighting Tumor Cell Survival: Advances in the Design and Evaluation of Pim Inhibitors

4. The Pim Kinases: New Targets for Drug Development

5. The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias.

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