Cytochrome P450 11A1 Bioactivation of a Kinase Inhibitor in Rats: Use of Radioprofiling, Modulation of Metabolism, and Adrenocortical Cell Lines to Evaluate Adrenal Toxicity-Reference-Cited by-同舟云学术

Cytochrome P450 11A1 Bioactivation of a Kinase Inhibitor in Rats: Use of Radioprofiling, Modulation of Metabolism, and Adrenocortical Cell Lines to Evaluate Adrenal Toxicity

Published:2012-03-02 Issue:3 Volume:25 Page:556-571
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Zhang Donglu¹,Flint Oliver¹,Wang Lifei¹,Gupta Ashok¹,Westhouse Richard A.¹,Zhao Weiping¹,Raghavan Nirmala¹,Caceres-Cortes Janet¹,Marathe Punit¹,Shen Guoxiang¹,Zhang Yueping¹,Allentoff Alban¹,Josephs Jonathan¹,Gan Jinping¹,Borzilleri Robert¹,Humphreys W. Griffith¹

Affiliation:

1. Department of Pharmaceutical Candidate Optimization, ‡Chemistry, and §Discovery Medicine and Clinical Pharmacology, Bristol-Myers Squibb Research & Development, Princeton, New Jersey 08543, United States

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx200524d

Reference47 articles.

1. Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily

2. Design, synthesis and structure–activity relationships of novel biarylamine-based Met kinase inhibitors

3. The Steroid Hormone Biosynthesis Pathway as a Target for Endocrine-Disrupting Chemicals

4. Histopathology of the human adrenal cortex

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