Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities-Reference-Cited by-同舟云学术

Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities

Published:2014-10-06 Issue:20 Volume:57 Page:8657-8663
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Galdeano Carles¹²,Gadd Morgan S.¹,Soares Pedro¹,Scaffidi Salvatore¹,Van Molle Inge²,Birced Ipek¹,Hewitt Sarah²,Dias David M.²,Ciulli Alessio¹²

Affiliation:

1. Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, U.K.

2. Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, U.K.

Funder

Research Executive Agency

European Research Council

Wellcome Trust

Biotechnology and Biological Sciences Research Council

Fundação para a Ciência e a Tecnologia

Ministero dell'Istruzione, dell'Università e della Ricerca

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm5011258

Reference23 articles.

1. The ubiquitin-proteasome proteolytic pathway

2. Drug discovery in the ubiquitin–proteasome system

3. Development of inhibitors in the ubiquitination cascade

4. The proteasome: a suitable antineoplastic target

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