HIV-1 Protease Inhibitors with a Transition-State Mimic Comprising a Tertiary Alcohol: Improved Antiviral Activity in Cells-Reference-Cited by-同舟云学术

HIV-1 Protease Inhibitors with a Transition-State Mimic Comprising a Tertiary Alcohol: Improved Antiviral Activity in Cells

Published:2009-12-04 Issue:2 Volume:53 Page:607-615
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mahalingam A.K.¹,Axelsson Linda¹,Ekegren Jenny K.¹,Wannberg Johan¹,Kihlström Jacob¹,Unge Torsten²,Wallberg Hans³,Samuelsson Bertil³,Larhed Mats¹,Hallberg Anders¹

Affiliation:

1. Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry, BMC, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden

2. Department of Cell and Molecular Biology, Structural Biology, BMC, Uppsala University, Box 596, SE-751 24 Uppsala, Sweden

3. Medivir AB, P.O. Box 1086, SE-141 44, Huddinge, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm901165g

Reference45 articles.

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2. HIV-1 protease: mechanism and drug discovery

3. Peptidomimetic Inhibitors of HIV Protease

4. HIV Protease Inhibitors: Peptidomimetic Drugs and Future Perspectives

5. HIV Protease Inhibition: Limited Recent Progress and Advances in Understanding Current Pitfalls

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