Rational Evolution of a Novel Type of Potent and Selective Proviral Integration Site in Moloney Murine Leukemia Virus Kinase 1 (PIM1) Inhibitor from a Screening-Hit Compound-Reference-Cited by-同舟云学术

Rational Evolution of a Novel Type of Potent and Selective Proviral Integration Site in Moloney Murine Leukemia Virus Kinase 1 (PIM1) Inhibitor from a Screening-Hit Compound

Published:2012-05-17 Issue:11 Volume:55 Page:5151-5164
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Nakano Hirofumi¹,Saito Nae¹,Parker Lorien²,Tada Yukio¹,Abe Masanao¹,Tsuganezawa Keiko²,Yokoyama Shigeyuki²,Tanaka Akiko¹²,Kojima Hirotatsu¹,Okabe Takayoshi¹,Nagano Tetsuo¹³

Affiliation:

1. Open Innovation Center for Drug Discovery, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

2. RIKEN Systems and Structural Biology Center, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan

3. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm3001289

Reference74 articles.

1. PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

2. Why target PIM1 for cancer diagnosis and treatment?

3. The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias.

4. Delineation of prognostic biomarkers in prostate cancer

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