Spirocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid β in a Higher Species-Reference-Cited by-同舟云学术

Spirocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid β in a Higher Species

Published:2013-04-16 Issue:8 Volume:56 Page:3379-3403
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hunt Kevin W.¹,Cook Adam W.¹,Watts Ryan J.²,Clark Christopher T.¹,Vigers Guy¹,Smith Darin¹,Metcalf Andrew T.¹,Gunawardana Indrani W.¹,Burkard Michael¹,Cox April A.¹,Geck Do Mary K.¹,Dutcher Darrin¹,Thomas Allen A.¹,Rana Sumeet¹,Kallan Nicholas C.¹,DeLisle Robert K.¹,Rizzi James P.¹,Regal Kelly¹,Sammond Douglas¹,Groneberg Robert¹,Siu Michael²,Purkey Hans²,Lyssikatos Joseph P.²,Marlow Allison¹,Liu Xingrong²,Tang Tony P.¹

Affiliation:

1. Array BioPharma, 3200 Walnut Street, Boulder, Colorado 80301, United States

2. Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4002154

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3. bThe response of the United States is markedly more modest: U.S. Department of Health & Human Services. National Plan To Address Alzheimer’s Disease (2nd draft).http://aspe.hhs.gov/daltcp/napa/NatlPlan.shtml.

4. Alzheimer's Disease: The Amyloid Cascade Hypothesis

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