Discovery and Development of the Covalent Hydrates of Trifluoromethylated Pyrazoles as Riboflavin Synthase Inhibitors with Antibiotic Activity Against Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Discovery and Development of the Covalent Hydrates of Trifluoromethylated Pyrazoles as Riboflavin Synthase Inhibitors with Antibiotic Activity Against Mycobacterium tuberculosis

Published:2009-06-22 Issue:15 Volume:74 Page:5297-5303
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Zhao Yujie¹,Bacher Adelbert²,Illarionov Boris³,Fischer Markus³,Georg Gunda⁴,Ye Qi-Zhuang⁴,Fanwick Phillip E.⁵,Franzblau Scott G.⁶,Wan Baojie⁶,Cushman Mark¹

Affiliation:

1. Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, and The Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907

2. Ikosatec GmbH, Königsbergerstrasse 74, 85748 Garching, Germany

3. Institute of Biochemistry and Food Chemistry, Food Chemistry Division, University of Hamburg, D-20146 Hamburg, Germany

4. Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66047

5. Department of Chemistry, Purdue University, West Lafayette, Indiana 47907

6. Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo900768c

Reference46 articles.

1. Biosynthesis of Vitamin B2 (Riboflavin)

2. Biosynthesis of Riboflavin. Studies on the Reaction Mechanism of 6,7-Dimethyl-8-ribityllumazine Synthase

3. Studies on the Reaction Mechanism of Riboflavin Synthase

4. A pentacyclic reaction intermediate of riboflavin synthase

5. Riboflavin Synthase of Escherichia coli

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