Discovery of a 3-Pyridylacetic Acid Derivative (TAK-100) as a Potent, Selective and Orally Active Dipeptidyl Peptidase IV (DPP-4) Inhibitor-Reference-Cited by-同舟云学术

Discovery of a 3-Pyridylacetic Acid Derivative (TAK-100) as a Potent, Selective and Orally Active Dipeptidyl Peptidase IV (DPP-4) Inhibitor

Published:2011-01-10 Issue:3 Volume:54 Page:831-850
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Miyamoto Yasufumi¹,Banno Yoshihiro¹,Yamashita Tohru¹,Fujimoto Tatsuhiko¹,Oi Satoru¹,Moritoh Yusuke¹,Asakawa Tomoko¹,Kataoka Osamu¹,Yashiro Hiroaki¹,Takeuchi Koji¹,Suzuki Nobuhiro¹,Ikedo Koji¹,Kosaka Takuo¹,Tsubotani Shigetoshi¹,Tani Akiyoshi¹,Sasaki Masako¹,Funami Miyuki¹,Amano Michiko¹,Yamamoto Yoshio¹,Aertgeerts Kathleen²,Yano Jason²,Maezaki Hironobu¹

Affiliation:

1. Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 17-85, Jusohonmachi 2-Chome, Yodogawa-ku, Osaka 532-8686, Japan

2. Takeda San Diego, Inc., 10410, Science Center Drive, San Diego, California 92121, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101236h

Reference38 articles.

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3. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum

4. Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV.

5. Review: DPP IV inhibitors - current evidence and future directions

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