Discovery of a Biaryl Cyclohexene Carboxylic Acid (MK-6892): A Potent and Selective High Affinity Niacin Receptor Full Agonist with Reduced Flushing Profiles in Animals as a Preclinical Candidate-Reference-Cited by-同舟云学术

Discovery of a Biaryl Cyclohexene Carboxylic Acid (MK-6892): A Potent and Selective High Affinity Niacin Receptor Full Agonist with Reduced Flushing Profiles in Animals as a Preclinical Candidate

Published:2010-02-25 Issue:6 Volume:53 Page:2666-2670
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shen Hong C.¹,Ding Fa-Xiang¹,Raghavan Subharekha¹,Deng Qiaolin¹,Luell Silvi²,Forrest Michael J.²,Carballo-Jane Ester²,Wilsie Larissa C.³,Krsmanovic Mihajlo L.³,Taggart Andrew K.³,Wu Kenneth K.³,Wu Tsuei-Ju³,Cheng Kang³,Ren Ning³,Cai Tian-Quan³,Chen Qing⁴,Wang Junying⁴,Wolff Michael S.⁴,Tong Xinchun⁴,Holt Tom G.⁴,Waters M. Gerard³,Hammond Milton L.¹,Tata James R.¹,Colletti Steven L.¹

Affiliation:

1. Departments of Medicinal Chemistry

2. Pharmacology

3. Cardiovascular Diseases

4. Drug Metabolism

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100022r

Reference20 articles.