1. Discovery Research Laboratories V and Pharmaceutical Research Division, Takeda Chemical Industries, Ltd., Yodogawa-ku, Osaka 532-8686, Japan, Pharmaceutical Discovery Research Division, Takeda Chemical Industries, Ltd., Wadai-10, Tsukuba, Ibaraki 300-4293, Japan, and Takeda Chemical Industries, Ltd., Chuo-ku, Osaka 541-0045, Japan