1. ATO, Agrotechnological Research Institute, Bornsesteeg 59, P.O. Box 17, NL-6700 AA Wageningen, The Netherlands, Ege University, Faculty of Engineering, Department of Bioengineering, 35100 İzmir, Turkey, and Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, P.O. Box 80.082, 3508 TB Utrecht, The Netherlands