1-(5-Carboxyindol-1-yl)propan-2-one Inhibitors of Human Cytosolic Phospholipase A2α with Reduced Lipophilicity: Synthesis, Biological Activity, Metabolic Stability, Solubility, Bioavailability, And Topical in Vivo Activity-Reference-Cited by-同舟云学术

1-(5-Carboxyindol-1-yl)propan-2-one Inhibitors of Human Cytosolic Phospholipase A2α with Reduced Lipophilicity: Synthesis, Biological Activity, Metabolic Stability, Solubility, Bioavailability, And Topical in Vivo Activity

Published:2010-06-29 Issue:14 Volume:53 Page:5165-5178
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Drews Andreas¹,Bovens Stefanie¹,Roebrock Kirsten²,Sunderkötter Cord³,Reinhardt Dirk⁴,Schäfers Michael⁴,van der Velde Andrea¹,Schulze Elfringhoff Alwine¹,Fabian Jörg¹,Lehr Matthias¹

Affiliation:

1. Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Hittorfstrasse 58-62, 48149 Münster, Germany

2. Institute of Immunology, Münster University Hospital, Röntgenstrasse 21, 48149 Münster, Germany

3. Department of Dermatology, Münster University Hospital, Von-Esmarch-Strasse 58, 48149 Münster, Germany

4. European Institute for Molecular Imaging (EIMI), University of Münster, Mendelstrasse 11, 48149 Münster, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm1001088

Reference44 articles.

1. Biochemical properties and pathophysiological roles of cytosolic phospholipase A2s

2. Properties of the Group IV phospholipase A2 family

3. Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2

4. Role of cytosolic phospholipase A2 in allergic response and parturition

5. Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2

Cited by 42 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. N,N-Disubstituted 4-Sulfamoylbenzoic Acid Derivatives as Inhibitors of Cytosolic Phospholipase A_2α: Synthesis, Aqueous Solubility, and Activity in a Vesicle and a Whole Blood Assay;Medicinal Chemistry;2024-12

2. Harnessing Medicinal Chemical Intuition from Collective Intelligence;2024-05-09

3. 1-Benzylindoles as inhibitors of cytosolic phospholipase A₂α: synthesis, biological activity, aqueous solubility, and cell permeability;RSC Medicinal Chemistry;2024

4. Synthesis, activity, metabolic stability and cell permeability of new cytosolic phospholipase A2α inhibitors with 1-indolyl-3-phenoxypropan-2-one structure;Bioorganic & Medicinal Chemistry Letters;2023-08

5. Synthesis and pharmacokinetic properties of novel cPLA2α inhibitors with 1-(carboxyalkylpyrrolyl)-3-aryloxypropan-2-one structure;Bioorganic & Medicinal Chemistry;2023-01