Highly Chiral Muscarinic Ligands: The Discovery of (2S,2‘R,3‘S,5‘R)-1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide Methyl Iodide, a Potent, Functionally Selective, M2 Partial Agonist-Reference-Cited by-同舟云学术

Highly Chiral Muscarinic Ligands: The Discovery of (2S,2‘R,3‘S,5‘R)-1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide Methyl Iodide, a Potent, Functionally Selective, M2 Partial Agonist

Published:2006-02-18 Issue:6 Volume:49 Page:1925-1931
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Scapecchi Serena¹,Matucci Rosanna¹,Bellucci Cristina¹,Buccioni Michela¹,Dei Silvia¹,Guandalini Luca¹,Martelli Cecilia¹,Manetti Dina¹,Martini Elisabetta¹,Marucci Gabriella¹,Nesi Marta¹,Romanelli Maria Novella¹,Teodori Elisabetta¹,Gualtieri Fulvio¹

Affiliation:

1. Dipartimento di Scienze Farmaceutiche, Università di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy, Dipartimento di Farmacologia Preclinica e Clinica, Università di Firenze, Viale Pieraccini 6, 50139 Firenze, Italy, and Dipartimento di Chimica, Università di Camerino, Via S.Agostino 1, 62032 Camerino (MC), Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0510878

Reference37 articles.

1. Muscarinic Receptors—Characterization, coupling and function

2. Muscarinic M1 agonists in the treatment of Alzheimer’s disease

3. Muscarinic-mediated analgesia

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