1. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan, Department of Applied Biological Science, Nihon University, Fujisawa, Kanagawa 252-8510, Japan, The Kitasato Institute, Shirokane, Minato-ku, Tokyo 108-8642, Japan, and Research & Development Division, Mitsubishi Pharma Corporation, Aoba-ku, Yokohama 227-0033, Japan