Design, Synthesis, and Biological Evaluation of Novel Investigational Nonapeptide KISS1R Agonists with Testosterone-Suppressive Activity
Author:
Affiliation:
1. Pharmaceutical Research Division, Shonan Research Center, Takeda Pharmaceutical Company Ltd, 2-26-1, Muraoka-Higashi Fujisawa, Kanagawa 251-8555, Japan
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm401056w
Reference17 articles.
1. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor
2. The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54
3. AXOR12, a Novel Human G Protein-coupled Receptor, Activated by the Peptide KiSS-1
4. Discovery of a receptor related to the galanin receptors
5. Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat
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