1. Department of Chemistry, University of Toronto, 80 St. George Street, Toronto M5S 3H6, Canada, The Blueprint Initiative, 522 University Avenue, Toronto M5G 1W7, Canada, EMBL, Mayerhofstrasse 1, Heidelberg, D6900 Germany, and School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom