Diarylthiazole: An Antimycobacterial Scaffold Potentially Targeting PrrB-PrrA Two-Component System

Author:

Bellale Eknath1,Naik Maruti1,VB Varun1,Ambady Anisha2,Narayan Ashwini2,Ravishankar Sudha2,Ramachandran Vasanthi2,Kaur Parvinder2,McLaughlin Robert3,Whiteaker James3,Morayya Sapna2,Guptha Supreeth2,Sharma Sreevalli2,Raichurkar Anandkumar1,Awasthy Disha2,Achar Vijayshree1,Vachaspati Prakash4,Bandodkar Balachandra1,Panda Manoranjan1,Chatterji Monalisa2

Affiliation:

1. Department of Medicinal Chemistry, IMED Infection, AstraZeneca, Bellary Road, Hebbal, Bangalore 560024, India

2. Department of Biosciences, IMED Infection, AstraZeneca, Bellary Road, Hebbal, Bangalore 560024, India

3. Infection IMED, AstraZeneca, GHP, Waltham, Massachusetts 02451, United States

4. DMPK and Animal Sciences, IMED Infection, AstraZeneca, Bellary Road, Hebbal, Bangalore 560024, India

Funder

AstraZeneca

Global Alliance for Tuberculosis Drug Development

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference30 articles.

1. Global Tuberculosis Report;World Health Organization:Geneva, Switzerland, 2012.

2. Meeting Report “Totally Drug-Resistant TB”: A WHO Consultation on the Diagnostic Definition and Treatment Options;WHO/HQ:Geneva, Switzerland, 2012.

3. Tuberculosis success

4. Development of Mycobacterium tuberculosis Whole Cell Screening Hits as Potential Antituberculosis Agents

5. New classes of antibacterial oxazolidinones with C-5, methylene O-Linked heterocyclic side chains

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