Structure−Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli-Reference-Cited by-同舟云学术

Structure−Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli

Published:2005-12-13 Issue:1 Volume:49 Page:159-171
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kim Pilho¹,Zhang Yong-Mei¹,Shenoy Gautham¹,Nguyen Quynh-Anh¹,Boshoff Helena I.¹,Manjunatha Ujjini H.¹,Goodwin Michael B.¹,Lonsdale John¹,Price Allen C.¹,Miller Darcie J.¹,Duncan Ken¹,White Stephen W.¹,Rock Charles O.¹,Barry Clifton E.¹,Dowd Cynthia S.¹

Affiliation:

1. Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, The Departments of Infectious Diseases and Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, and GlaxoSmithKline, Upper Providence, Pennsylvania and Stevenage, UK

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050825p

Reference56 articles.

1. World Health Organization Tuberculosis Fact Sheet No. 104; World Health Organization: Geneva, Switzerland, April 2005;http://www.who.int/mediacentre/factsheets/fs104/en/.

2. Prospects for new antitubercular drugs

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