Introduction of All-Hydrocarbon i,i+3 Staples into α-Helices via Ring-Closing Olefin Metathesis-Reference-Cited by-同舟云学术

Introduction of All-Hydrocarbon i,i+3 Staples into α-Helices via Ring-Closing Olefin Metathesis

Published:2010-06-07 Issue:13 Volume:12 Page:3046-3049
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Kim Young-Woo¹,Kutchukian Peter S.¹,Verdine Gregory L.¹

Affiliation:

1. Departments of Chemistry and Chemical Biology, Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, and Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ol1010449

Reference26 articles.

1. A Highly Stable Short α-Helix Constrained by a Main-Chain Hydrogen-Bond Surrogate

2. Enhanced Metabolic Stability and Protein-Binding Properties of Artificial α Helices Derived from a Hydrogen-Bond Surrogate: Application to Bcl-xL

3. For recent reviews, see:

4. Contemporary strategies for the stabilization of peptides in the α-helical conformation

5. Design and synthesis of α-helical peptides and mimetics

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