Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2‘-(aminosulfonyl)[1,1‘-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor-Reference-Cited by-同舟云学术

Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2‘-(aminosulfonyl)[1,1‘-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor

Published:2003-10-29 Issue:25 Volume:46 Page:5298-5315
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pruitt James R.¹,Pinto Donald J. P.¹,Galemmo, Robert A.¹,Alexander Richard S.¹,Rossi Karen A.¹,Wells Brian L.¹,Drummond Spencer¹,Bostrom Lori L.¹,Burdick Debra¹,Bruckner Robert¹,Chen Haiying¹,Smallwood Angela¹,Wong Pancras C.¹,Wright Matthew R.¹,Bai Steven¹,Luettgen Joseph M.¹,Knabb Robert M.¹,Lam Patrick Y. S.¹,Wexler Ruth R.¹

Affiliation:

1. Bristol-Myers Squibb Company, Pharmaceutical Research Institute, 31 Pennington-Rocky Hill Road, Pennington, New Jersey 08534

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030212h

Reference44 articles.

1. Direct thrombin inhibitors in cardiovascular medicine.

Cited by 78 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Construction of 1,4‐Oxazepinones via a Cascade Aza‐Michael/S_N2 Annulation of Trifluoromethyl Pyrazole‐Derived Oxadienes with a‐Bromohydroxamates;Asian Journal of Organic Chemistry;2024-08-21

2. Isolation, synthesis and medicinal chemistry of biphenyl analogs – A review;Results in Chemistry;2023-12

3. Torsion angles to map and visualize the conformational space of a protein;Protein Science;2023-03-17

4. Discovery and development of Factor Xa inhibitors (2015–2022);Frontiers in Pharmacology;2023-02-21

5. Design, Synthesis and Pharmacological Evaluation of Novel C2,C3-Quinoxaline Derivatives as Promising Anxiolytic Agents;International Journal of Molecular Sciences;2022-11-19