1. Department of Structural and Functional Biology, University of Insubria, Via J. H. Dunant 3, 21100 Varese VA, Italy, Centre for Chemicals Management and Environmental Science Department, Lancaster Environment Centre, Lancaster University, Lancaster, LA1 4YQ, UK, and Department of Chemical and Environmental Sciences, University of Insubria, Via Valleggio, 11, 22100 Como CO, Italy