Small, Potent, and Selective Diaryl Phosphonate Inhibitors for Urokinase-Type Plasminogen Activator with In Vivo Antimetastatic Properties-Reference-Cited by-同舟云学术

Small, Potent, and Selective Diaryl Phosphonate Inhibitors for Urokinase-Type Plasminogen Activator with In Vivo Antimetastatic Properties

Published:2007-12-01 Issue:26 Volume:50 Page:6638-6646
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Joossens Jurgen¹,Ali Omar M.¹,El-Sayed Ibrahim¹,Surpateanu Georgiana¹,Van der Veken Pieter¹,Lambeir Anne-Marie¹,Setyono-Han Buddy¹,Foekens John A.¹,Schneider Anneliese¹,Schmalix Wolfgang¹,Haemers Achiel¹,Augustyns Koen¹

Affiliation:

1. Laboratory of Medicinal Chemistry and Laboratory of Medical Biochemistry, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium, Erasmus MC, Josephine Nefkens Institute, Department of Medical Oncology, Dr. Molewaterplein 50, 3015 GE Rotterdam, Netherlands, and Wilex AG, Grillparzestr. 10, 81675 Munich, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm700962j

Reference42 articles.

1. Plasminogen activation and cancer

2. The urokinase receptor and the regulation of cell proliferation

3. The Urokinase Plasminogen Activator System: Role in Malignancy

4. Design of Novel and Selective Inhibitors of Urokinase-type Plasminogen Activator with Improved Pharmacokinetic Properties for Use as Antimetastatic Agents

5. Suppression of rat breast cancer metastasis and reduction of primary tumour growth by the small synthetic urokinase inhibitor WX-UK1

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