Design, Synthesis, and Antileukemic Activity of Stereochemically Defined Constrained Analogues of FTY720 (Gilenya)
Author:
Affiliation:
1. Department of Chemistry, Université de Montréal, Station Centre-Ville, Montréal, Quebec H3C 3J7, Canada
2. Department of Developmental and Cell Biology, University of California, Irvine, 2128 Natural Sciences 1, California 92697, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ml4002425
Reference21 articles.
1. FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system
2. FTY720 S‐ene‐phosphonate is a novel pan‐antagonist of the S1P receptors that inhibits lymphocyte egress
3. Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: Discovery of potent S1P1 receptor agonists
4. Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors
5. Sphingosine 1-Phosphate Analogs as Receptor Antagonists
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