The Total Synthesis of Dynemicin A Leading to Development of a Fully Contained Bioreductively Activated Enediyne Prodrug-Reference-Cited by-同舟云学术

The Total Synthesis of Dynemicin A Leading to Development of a Fully Contained Bioreductively Activated Enediyne Prodrug

Published:1996-01-01 Issue:40 Volume:118 Page:9509-9525
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Shair Matthew D.¹,Yoon Tae Young¹,Mosny Karoline K.¹,Chou T. C.¹,Danishefsky Samuel J.¹

Affiliation:

1. Contribution from the Department of Chemistry, Yale University, New Haven, Connecticut 06511, the Laboratories for Bio-Organic Chemistry and Biochemical Pharmacology, The Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, and the Department of Chemistry, Columbia University, New York, New York 10027

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja960040w

Reference50 articles.

1. Dynemicin A, a novel antibiotic with the anthraquinone and 1,5-diyn-3-ene subunit.

2. Crystal and molecular structure of dynemicin A: a novel 1,5-diyn-3-ene antitumor antibiotic

3. Observations in the Chemistry and Biology of Cyclic Enediyne Antibiotics: Total Syntheses of Calicheamicin γ1I and Dynemicin A

4. Calichemicins, a novel family of antitumor antibiotics. 1. Chemistry and partial structure of calichemicin .gamma.1I

5. Calichemicins, a novel family of antitumor antibiotics. 2. Chemistry and structure of calichemicin .gamma.1I

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