Alteration of the Substrate’s Prefolded Conformation and Cyclization Stereochemistry of Oxidosqualene-Lanosterol Cyclase of Saccharomyces cerevisiae by Substitution at Phenylalanine 699-Reference-Cited by-同舟云学术

Alteration of the Substrate’s Prefolded Conformation and Cyclization Stereochemistry of Oxidosqualene-Lanosterol Cyclase of Saccharomyces cerevisiae by Substitution at Phenylalanine 699

Published:2010-01-07 Issue:3 Volume:12 Page:500-503
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Wu Tung-Kung¹,Chang Cheng-Hsiang¹,Wen Hao-Yu¹,Liu Yuan-Ting¹,Li Wen-Hsuan¹,Wang Tsai-Ting¹,Shie Wen-Shiang¹

Affiliation:

1. Department of Biological Science and Technology, National Chiao Tung University, 300, Hsin-Chu, Taiwan, Republic of China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ol902694y

Reference51 articles.

1. De novo design of biocatalysts

2. Designed divergent evolution of enzyme function

3. Enzymatic cyclization of squalene and oxidosqualene to sterols and triterpenes

4. Enzyme Mechanisms for Polycyclic Triterpene Formation

Cited by 19 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Discovering a uniform functional trade-off of the CBC-type 2,3-oxidosqualene cyclases and deciphering its chemical logic;Science Advances;2023-06-09

2. Engineering Critical Amino Acid Residues of Lanosterol Synthase to Improve the Production of Triterpenoids in Saccharomyces cerevisiae;ACS SYNTH BIOL;2022

3. Engineering Critical Amino Acid Residues of Lanosterol Synthase to Improve the Production of Triterpenoids in Saccharomyces cerevisiae;ACS Synthetic Biology;2022-08-03

4. Biosynthetic Mechanism of Lanosterol: A Completed Story;ACS Catalysis;2020-01-13

5. Oryza sativa Parkeol Cyclase: Changes in the Substrate‐Folding Conformation and the Deprotonation Sites on Mutation at Tyr257: Importance of the Hydroxy Group and Steric Bulk;ChemBioChem;2019-10-15