Synthesis of Trifluoromethylaryl Diazirine and Benzophenone Derivatives of Etomidate that Are Potent General Anesthetics and Effective Photolabels for Probing Sites on Ligand-Gated Ion Channels-Reference-Cited by-同舟云学术

Synthesis of Trifluoromethylaryl Diazirine and Benzophenone Derivatives of Etomidate that Are Potent General Anesthetics and Effective Photolabels for Probing Sites on Ligand-Gated Ion Channels

Published:2006-07-07 Issue:16 Volume:49 Page:4818-4825
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Husain S. Shaukat¹,Nirthanan Selvanayagam¹,Ruesch Dirk¹,Solt Ken¹,Cheng Qi¹,Li Guo-Dong¹,Arevalo Enrique¹,Olsen Richard W.¹,Raines Douglas E.¹,Forman Stuart A.¹,Cohen Jonathan B.¹,Miller Keith W.¹

Affiliation:

1. Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, Department of Biological Chemistry and Molecular Pharmacology, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, and Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm051207b

Reference37 articles.

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3. The interaction of general anaesthetics with recombinant GABAA and glycine receptors expressed in Xenopus laevis oocytes: a comparative study

4. Lambert, J. J.; Belelli, D.; Shepard, S.; Muntoni, A.L.; Pistis, M.; Peters, J. A. The GABA Receptor: An Important Locus for Intravenous Anaesthetic Action.Gases in Medicine: Anæsthesia; Royal Society of Chemistry: Cambridge, 1998; pp 121−137.

5. Gating Allosterism at a Single Class of Etomidate Sites on α1β2γ2L GABAA Receptors Accounts for Both Direct Activation and Agonist Modulation

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