Conformational Restriction by Repulsion between Adjacent Substituents on a Cyclopropane Ring: Design and Enantioselective Synthesis of 1-Phenyl-2-(1-aminoalkyl)-N,N-diethylcyclopropanecarboxamides as Potent NMDA Receptor Antagonists-Reference-Cited by-同舟云学术

Conformational Restriction by Repulsion between Adjacent Substituents on a Cyclopropane Ring: Design and Enantioselective Synthesis of 1-Phenyl-2-(1-aminoalkyl)-N,N-diethylcyclopropanecarboxamides as Potent NMDA Receptor Antagonists

Published:1996-01-01 Issue:3 Volume:61 Page:915-923
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Shuto Satoshi¹,Ono Shizuka¹,Hase Yukako¹,Kamiyama Noriko¹,Takada Hironao¹,Yamasihita Kanako¹,Matsuda Akira¹

Affiliation:

1. Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060, Japan and Institute for Life Science Research, Asahi Chemical Industry Co., Ltd., Mifuku, Ohito-cho, Shizuoka 410-23, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo9518056

Reference45 articles.

1. Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

2. Benzo- and pyrido-1,4-oxazepin-5-ones and -thiones: synthesis and structure-activity relationships of a new series of H1-antihistamines

3. The behavioral pharmacology of NMDA receptor antagonists

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