(S)-(−)-5-Ethynyl-3-(1-methyl-2-pyrroli- dinyl)pyridine Maleate (SIB-1508Y):  A Novel Anti-Parkinsonian Agent with Selectivity for Neuronal Nicotinic Acetylcholine Receptors

Author:

Cosford Nicholas D. P.1,Bleicher Leo1,Herbaut Audrey1,McCallum J. Stuart1,Vernier Jean-Michel1,Dawson Heather1,Whitten Jeffrey P.1,Adams Pamala1,Chavez-Noriega Laura1,Correa Lucia D.1,Crona James H.1,Mahaffy Lorrence S.1,Menzaghi Frederique1,Rao Tadimeti S.1,Reid Richard1,Sacaan Aida I.1,Santori Emily1,Stauderman Kenneth A.1,Whelan Kevin1,Lloyd G. Kenneth1,McDonald Ian A.1

Affiliation:

1. SIBIA Neurosciences Inc., 505 Coast Boulevard South, Suite 300, La Jolla, California 92037

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference29 articles.

1. The Diversity of Neuronal Nicotinic Acetylcholine Receptors

2. Diversity and Patterns of Regulation of Nicotinic Receptor Subtypesa

3. Arneric, S. P.; Williams, M. Nicotinic Agonists in Alzheimer's Disease:  Does the Molecular Diversity of Nicotine Receptors Offer the Opportunity for Developing CNS-Selective Cholinergic Channel Activators? InInternational Academy of Biomedical Drug Research; Racagni, G., Brunello, N., Langer, S. Z., Eds.; S. Karger:  Basel, 1994; Vol. 7, pp 58−70.

4. The Pharmacotherapy of Alzheimer's Disease Based on the Cholinergic Hypothesis: an Update

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