Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment-Reference-Cited by-同舟云学术

Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment

Published:2015-10-06 Issue:11 Volume:6 Page:1128-1133
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Ammirati Mark¹,Bagley Scott W.¹,Bhattacharya Samit K.¹,Buckbinder Leonard¹,Carlo Anthony A.¹,Conrad Rebecca¹,Cortes Christian¹,Dow Robert L.¹,Dowling Matthew S.¹,El-Kattan Ayman¹,Ford Kristen¹,Guimarães Cristiano R. W.¹,Hepworth David¹,Jiao Wenhua¹,LaPerle Jennifer¹,Liu Shenping¹,Londregan Allyn¹,Loria Paula M.¹,Mathiowetz Alan M.¹,Munchhof Michael¹,Orr Suvi T. M.¹,Petersen Donna N.¹,Price David A.¹,Skoura Athanasia¹,Smith Aaron C.¹,Wang Jian¹

Affiliation:

1. Worldwide Medicinal Chemistry, ‡Cardiovascular and Metabolic Research Unit, §External Research Solutions, ∥Primary Pharmacology Group, and ⊥Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.5b00215

Reference21 articles.

1. A Novel Human STE20-related Protein Kinase, HGK, That Specifically Activates the c-Jun N-terminal Kinase Signaling Pathway

2. Expression of MAP4K4 Is Associated with Worse Prognosis in Patients with Stage II Pancreatic Ductal Adenocarcinoma

3. An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARγ, adipogenesis, and insulin-responsive hexose transport

4. Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

5. MAP4K4 Gene Silencing in Human Skeletal Muscle Prevents Tumor Necrosis Factor-α-induced Insulin Resistance

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