Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors-Reference-Cited by-同舟云学术

Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors

Published:2016-01-20 Issue:3 Volume:7 Page:217-222
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Lin Hong¹,Zeng Jin¹,Xie Ren¹,Schulz Mark J.¹,Tedesco Rosanna¹,Qu Junya¹,Erhard Karl F.¹,Mack James F.¹,Raha Kaushik¹,Rendina Alan R.¹,Szewczuk Lawrence M.¹,Kratz Patricia M.¹,Jurewicz Anthony J.¹,Cecconie Ted¹,Martens Stan¹,McDevitt Patrick J.¹,Martin John D.¹,Chen Stephenie B.¹,Jiang Yong¹,Nickels Leng¹,Schwartz Benjamin J.¹,Smallwood Angela¹,Zhao Baoguang¹,Campobasso Nino¹,Qian Yanqiu¹,Briand Jacques¹,Rominger Cynthia M.¹,Oleykowski Catherine¹,Hardwicke Mary Ann¹,Luengo Juan I.¹

Affiliation:

1. Cancer Metabolism Chemistry; ‡Cancer Metabolism Biology; and §Platform Technology & Sciences, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426-0989, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.5b00214

Reference14 articles.

1. Glycolysis inhibition for anticancer treatment

2. Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy

3. Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention

4. Evaluation of the Role of Hexokinase Type II in Cellular Proliferation and Apoptosis Using Human Hepatocellular Carcinoma Cell Lines

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