Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors-Reference-Cited by-同舟云学术

Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors

Published:2015-03-18 Issue:5 Volume:6 Page:523-527
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Gavai Ashvinikumar V.¹,Quesnelle Claude¹,Norris Derek¹,Han Wen-Ching¹,Gill Patrice¹,Shan Weifang¹,Balog Aaron¹,Chen Ke²,Tebben Andrew¹,Rampulla Richard¹,Wu Dauh-Rurng¹,Zhang Yingru¹,Mathur Arvind¹,White Ronald¹,Rose Anne¹,Wang Haiqing¹,Yang Zheng¹,Ranasinghe Asoka¹,D’Arienzo Celia¹,Guarino Victor¹,Xiao Lan¹,Su Ching¹,Everlof Gerry¹,Arora Vinod³,Shen Ding Ren¹,Cvijic Mary Ellen¹,Menard Krista¹,Wen Mei-Li¹,Meredith Jere³,Trainor George¹,Lombardo Louis J.¹,Olson Richard³,Baran Phil S.²,Hunt John T.¹,Vite Gregory D.¹,Fischer Bruce S.¹,Westhouse Richard A.¹,Lee Francis Y.¹

Affiliation:

1. Bristol-Myers Squibb Research and Development, Princeton, New Jersey 08543, United States

2. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States

3. Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.5b00001

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1. Targeting Notch signaling pathway in cancer: Clinical development advances and challenges

2. Notch signalling in solid tumours: a little bit of everything but not all the time

3. γ-Secretase inhibitors and modulators

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