Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo-Reference-Cited by-同舟云学术

Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo

Published:2016-01-29 Issue:3 Volume:7 Page:300-305
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Dowling James E.¹,Alimzhanov Marat¹,Bao Larry¹,Chuaqui Claudio¹,Denz Christopher R.¹,Jenkins Emma¹,Larsen Nicholas A.¹,Lyne Paul D.¹,Pontz Timothy¹,Ye Qing¹,Holdgate Geoff A.²,Snow Lindsay²,O’Connell Nichole³,Ferguson Andrew D.³

Affiliation:

1. Oncology Innovative Medicines Unit, AstraZeneca R&D, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States

2. Structure & Biophysics, Discovery Sciences, AstraZeneca R&D, Darwin Building, 310 Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, U.K.

3. Structure & Biophysics, Discovery Sciences, AstraZeneca R&D, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.5b00452

Reference16 articles.

1. Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme

2. Addiction to protein kinase CK2: A common denominator of diverse cancer cells?

3. Discovery and SAR of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the First Clinical Stage Inhibitor of Protein Kinase CK2 for the Treatment of Cancer

4. Wnt/β-Catenin Signaling and Disease

5. Protein Kinase CK2 in Health and Disease

Cited by 47 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2;Molecules;2024-09-02

2. More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5-a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication;Journal of Medicinal Chemistry;2024-07-03

3. CK2 Inhibitors Targeting Inside and Outside the Catalytic Box;Kinases and Phosphatases;2024-03-26

4. Capillary Electrophoresis-Based Protein Kinase Ck2 Inhibitor Testing;2024

5. Casein kinase (CK) inhibitors;Current Molecular Targets of Heterocyclic Compounds for Cancer Therapy;2024