Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis

Author:

Sidhu Alpa1,Miller Justin R.1,Tripathi Ashootosh2,Garshott Danielle M.1,Brownell Amy L.1,Chiego Daniel J.3,Arevang Carl2,Zeng Qinghua1,Jackson Leah C.1,Bechler Shelby A.1,Callaghan Michael U.1,Yoo George H.4,Sethi Seema5,Lin Ho-Sheng4,Callaghan Joseph H.6,Tamayo-Castillo Giselle7,Sherman David H.2,Kaufman Randal J.8,Fribley Andrew M.149

Affiliation:

1. Carmen and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan 48201, United States

2. Life Sciences Institute and Departments of Medicinal Chemistry, Chemistry, Microbiology & Immunology, University of Michigan, Ann Arbor, Michigan 48109, United States

3. Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan 48109, United States

4. Department of Otolaryngology, Wayne State University and Karmanos Cancer Institute, Detroit, Michigan 48201, United States

5. Department of Pathology, Wayne State University and Karmanos Cancer Institute, Detroit, Michigan 48201, United States

6. School of Business Administration, Oakland University, Rochester, Michigan 48309, United States

7. Instituto Nacional de Biodiversidad, CIPRONA-Escuela de Química, Universidad de Costa Rica, 3100 Heredia, Costa Rica

8. Degenerative Disease Research Program, Center for Cancer Research, Sanford|Burnham Medical Research Institute, La Jolla, California 92037, United States

9. Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, United States

Funder

Detroit Country Day School

Hyundai Hope On Wheels

National Institute of Diabetes and Digestive and Kidney Diseases

National Heart, Lung, and Blood Institute

Fogarty International Center

National Institute of Dental and Craniofacial Research

Children's Research Foundation of Michigan

Wayne State University Fund For Medical Research

College of Pharmacy, University of Michigan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

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