Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis-Reference-Cited by-同舟云学术

Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis

Published:2015-12-30 Issue:2 Volume:7 Page:198-203
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Liu Jian¹,Guiadeen Deodial¹,Krikorian Arto¹,Gao Xiaolei¹,Wang James¹,Boga Sobhana Babu¹,Alhassan Abdul-Basit¹,Yu Younong¹,Vaccaro Henry¹,Liu Shilan²,Yang Chundao²,Wu Hao²,Cooper Alan¹,de Man Jos¹,Kaptein Allard¹,Maloney Kevin¹,Hornak Viktor¹,Gao Ying-Duo¹,Fischmann Thierry O.¹,Raaijmakers Hans¹,Vu-Pham Diep¹,Presland Jeremy¹,Mansueto My¹,Xu Zangwei¹,Leccese Erica¹,Zhang-Hoover Jie¹,Knemeyer Ian¹,Garlisi Charles G.¹,Bays Nathan¹,Stivers Peter¹,Brandish Philip E.¹,Hicks Alexandra¹,Kim Ronald¹,Kozlowski Joseph A.¹

Affiliation:

1. Department of Early Development and Discovery Sciences, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States

2. WuXi PharmaTech Co. Ltd, 288 FuTe Zhong Road, No. 1 Building, WaiGaoQiao Free Trade Zone, Shanghai 200131, P. R. China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.5b00463

Reference11 articles.

1. Emerging cell and cytokine targets in rheumatoid arthritis

2. Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection

3. Pfizer's JAK inhibitor sails through phase 3 in rheumatoid arthritis

4. The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

5. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

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