Discovery of a Potent and Orally Efficacious TGR5 Receptor Agonist-Reference-Cited by-同舟云学术

Discovery of a Potent and Orally Efficacious TGR5 Receptor Agonist

Published:2015-11-25 Issue:1 Volume:7 Page:51-55
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Agarwal Sameer¹,Patil Amit¹,Aware Umesh¹,Deshmukh Prashant¹,Darji Brijesh¹,Sasane Santosh¹,Sairam Kalapatapu V. V. M.¹,Priyadarsiny Priyanka¹,Giri Poonam¹,Patel Harilal¹,Giri Suresh¹,Jain Mukul¹,Desai Ranjit C.¹

Affiliation:

1. Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N.H. No. 8 A, Moraiya, Ahmedabad 382 210, India

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.5b00323

Reference30 articles.

1. From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus

2. Risk of macrovascular and microvascular complications in Type 2 diabetes

3. Pathophysiology and Treatment of Diabetic Peripheral Neuropathy: The Case for Diabetic Neurovascular Function as an Essential Component

4. Pharmacological Agents That Directly Modulate Insulin Secretion

Cited by 32 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets;Signal Transduction and Targeted Therapy;2024-04-26

2. Recent advancements in the structural exploration of TGR5 agonists for diabetes treatment;RSC Medicinal Chemistry;2024

3. Identification of potential drug candidates as TGR5 agonist to combat type II diabetes using in silico docking and molecular dynamics simulation studies;Journal of Biomolecular Structure and Dynamics;2023-02-01

4. Functional, Diagnostic and Therapeutic Aspects of Bile;Clinical and Experimental Gastroenterology;2022-07

5. ZY12201: A Potent TGR5 Agonist: Identification of a Novel Pan CYP450 Inhibitor Tool Compound for In-Vitro Assessment;Drug Metabolism and Bioanalysis Letters;2022-07