Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-Encoded Library Technology (ELT)-Reference-Cited by-同舟云学术

Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-Encoded Library Technology (ELT)

Published:2015-07-23 Issue:8 Volume:6 Page:888-893
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Ding Yun¹,O’Keefe Heather¹,DeLorey Jennifer L.²,Israel David I.¹,Messer Jeffrey A.¹,Chiu Cynthia H.¹,Skinner Steven R.¹,Matico Rosalie E.³,Murray-Thompson Monique F.³,Li Fan⁴,Clark Matthew A.⁵,Cuozzo John W.⁵,Arico-Muendel Christopher¹,Morgan Barry A.⁶

Affiliation:

1. Platform Technology & Science, GlaxoSmithKline, ELT-Boston, 830 Winter Street, Waltham, Massachusetts 02451, United States

2. Tedor Pharma, Inc., 400 Highland Corporate Drive, Cumberland, Rhode Island 02864, United States

3. Biological Reagent and Assay Development, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States

4. Tufts Healthcare Institute, 136 Harrison Avenue, Boston, Massachusetts 02111, United States

5. X-Chem, Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States

6. Center for Drug Discovery, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.5b00138

Reference21 articles.

1. Progress Towards the Identification of New Aggrecanase Inhibitors

2. Inhibition of ADAM-TS4 and ADAM-TS5 Prevents Aggrecan Degradation in Osteoarthritic Cartilage

3. Disease-Modifying Therapies for Osteoarthritis

4. The ADAMTS metalloproteinases

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