Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors-Reference-Cited by-同舟云学术

Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors

Published:2015-07-15 Issue:8 Volume:6 Page:942-947
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Seganish W. Michael¹,Fischmann Thierry O.¹,Sherborne Brad¹,Matasi Julius¹,Lavey Brian¹,McElroy William T.¹,Tulshian Deen¹,Tata James¹,Sondey Christopher¹,Garlisi Charles G.¹,Devito Kristine¹,Fossetta James¹,Lundell Daniel¹,Niu Xiaoda¹

Affiliation:

1. Discovery Chemistry, ‡Structural Sciences, §Computational Chemistry, ∥In Vitro Pharmacology, and ⊥Respiratory and Immunology, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.5b00279

Reference15 articles.

1. IRAK4 Kinase Activity Is Required for Th17 Differentiation and Th17-Mediated Disease

2. The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells

3. Signalling mechanisms for Toll-like receptor-activated neutrophil exocytosis: key roles for interleukin-1-receptor-associated kinase-4 and phosphatidylinositol 3-kinase but not Toll/IL-1 receptor (TIR) domain-containing adaptor inducing IFN-β (TRIF)

4. Toll-like receptor signalling

5. IRAK-4 – a shared NF-κB activator in innate and acquired immunity

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