Discovery of a High Affinity Adenosine A1/A3 Receptor Antagonist with a Novel 7-Amino-pyrazolo[3,4-d]pyridazine Scaffold-Reference-Cited by-同舟云学术

Discovery of a High Affinity Adenosine A₁/A₃ Receptor Antagonist with a Novel 7-Amino-pyrazolo[3,4-d]pyridazine Scaffold

Published:2022-05-31 Issue:6 Volume:13 Page:923-934
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Suchankova Anna¹,Stampelou Margarita²,Koutsouki Klontiana²³,Pousias Athanasios²,Dhingra Lakshiv¹,Barkan Kerry¹,Pouli Nicole²,Marakos Panagiotis²,Tenta Roxane³,Kolocouris Antonios²^ORCID,Lougiakis Nikolaos²,Ladds Graham¹^ORCID

Affiliation:

1. Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U.K.

2. Laboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771 Athens, Greece

3. Department of Nutrition & Dietetics, School of Health Sciences and Education, Harokopio University, 17671 Athens, Greece

Funder

Leverhulme Trust

University of Cambridge

Research Councils UK

Chiesi Hellas

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00052