Identification of Inhibitors of the <i>Schistosoma mansoni</i> VKR2 Kinase Domain-Reference-Cited by-同舟云学术

Identification of Inhibitors of the Schistosoma mansoni VKR2 Kinase Domain

Published:2022-10-05 Issue:11 Volume:13 Page:1715-1722
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Mathavan Indran¹²,Liu Lawrence J.³,Robinson Sean W.⁴^ORCID,El-Sakkary Nelly³,Elatico Adam Jo J.⁵^ORCID,Gomez Darwin⁵,Nellas Ricky⁵,Owens Raymond J.⁶⁷^ORCID,Zuercher William⁸^ORCID,Navratilova Iva⁴^ORCID,Caffrey Conor R.³,Beis Konstantinos¹²^ORCID

Affiliation:

1. Department of Life Sciences, Imperial College London, Exhibition Road, London, South Kensington SW7 2AZ, United Kingdom

2. Rutherford Appleton Laboratory, Research Complex at Harwell, Didcot, Oxfordshire OX11 0FA, United Kingdom

3. Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States

4. Kinetic Discovery Ltd., an Exscientia group company, The Schrödinger Building, Oxford Science Park, Oxford OX4 4GE, United Kingdom

5. Institute of Chemistry, College of Science, University of the Philippines Diliman, Quezon City, Philippines 1101

6. The Rosalind Franklin Institute, Harwell Campus, Didcot, OX11 0QX, United Kingdom

7. Division of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom

8. Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina 27599, United States

Funder

Medical Research Council

National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00248

Reference35 articles.

1. Human schistosomiasis

2. Schistosomiasis