Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448)

Author:

Heppner David E.12,Wittlinger Florian3ORCID,Beyett Tyler S.45,Shaurova Tatiana2,Urul Daniel A.6,Buckley Brian7,Pham Calvin D.1,Schaeffner Ilse K.45,Yang Bo45,Ogboo Blessing C.1,May Earl W.6,Schaefer Erik M.6,Eck Michael J.45,Laufer Stefan A.389ORCID,Hershberger Pamela A.2

Affiliation:

1. Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260, United States

2. Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States

3. Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany

4. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States

5. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States

6. AssayQuant Technologies, Inc., 260 Cedar Hill St., Marlboro, Massachusetts 01752, United States

7. Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14203, United States

8. Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls Universität Tübingen, 72076 Tübingen, Germany

9. Tübingen Center for Academic Drug Discovery & Development (TüCAD2), 72076 Tübingen, Germany

Funder

National Center for Advancing Translational Sciences

National Cancer Institute

Deutsche Forschungsgemeinschaft

Roswell Park Alliance Foundation, Roswell Park Cancer Institute

State University of New York

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

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