Discovery of Antibacterial Contezolid Acefosamil: Innovative <i>O</i>-Acyl Phosphoramidate Prodrug for IV and Oral Therapies-Reference-Cited by-同舟云学术

Discovery of Antibacterial Contezolid Acefosamil: Innovative O-Acyl Phosphoramidate Prodrug for IV and Oral Therapies

Published:2022-06-29 Issue:7 Volume:13 Page:1030-1035
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Liu Jinqian¹^ORCID,Wang Wen¹,Wang Changqing²,Zhang Li²,Zhang Xueliang²,Liu Shicong²,Xu Yunhua²,Wang Hailin²,Dai Qing²,Liu Chun²,Wang Xinghai²,Yuan Zhengyu¹,Gordeev Mikhail F.¹^ORCID

Affiliation:

1. MicuRx Pharmaceuticals, Inc., Foster City, California 94404, United States

2. Shanghai MicuRx Pharmaceutical Co. Ltd., Pudong New Area, Shanghai 201203, PR China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00191

Reference25 articles.

1. New Potent Antibacterial Oxazolidinone (MRX-I) with an Improved Class Safety Profile

2. In vitro Activity of Contezolid Against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus, and Strains With Linezolid Resistance Genes From China

3. In Vitro Activity and Potency of the Novel Oxazolidinone Contezolid (MRX-I) Tested against Gram-Positive Clinical Isolates from the United States and Europe

4. In VivoAntibacterial Activity of MRX-I, a New Oxazolidinone

5. A Phase III multicentre, randomized, double-blind trial to evaluate the efficacy and safety of oral contezolid versus linezolid in adults with complicated skin and soft tissue infections

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