Highly Potent and Oral Macrocyclic Peptides as a HIV-1 Protease Inhibitor: mRNA Display-Derived Hit-to-Lead Optimization
Author:
Affiliation:
1. Shionogi Pharmaceutical Research Center, Shionogi & Co., Ltd. 1-1, Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan
Funder
Shionogi
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00310
Reference34 articles.
1. Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)
2. Isolation of Human T-Cell Leukemia Virus in Acquired Immune Deficiency Syndrome (AIDS)
3. HIV-1 protease: mechanism and drug discovery
4. Conserved Folding in Retroviral Proteases: Crystal Structure of Synthetic HIV-1 Protease
5. X-ray analysis of HIV-1 proteinase at 2.7 Å resolution confirms structural homology among retroviral enzymes
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