Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties

Author:

Hill Matthew D.1,Fang Haiquan2,Norris Derek3,Delucca George V.3,Huang Hong2,DeBenedetto Mikkel2,Quesnelle Claude3,Schmitz William D.3,Tokarski John S.3,Sheriff Steven3,Yan Chunhong3,Fanslau Caroline3,Haarhoff Zuzana3,Huang Christine3,Kramer Melissa2,Madari Shilpa3,Menard Krista3,Monereau Laura3,Morrison John3,Raghavan Nirmala3,Shields Eric E.2,Simmermacher-Mayer Jean2,Sinz Michael3,Tye Ching Kim3,Westhouse Richard3,Xie Chunshan3,Zhang Haiying3,Zhang Lisa3,Zvyaga Tatyana3,Lee Francis3,Gavai Ashvinikumar V.3,Degnan Andrew P.3ORCID

Affiliation:

1. Research & Development, Bristol Myers Squibb Company, 100 Binney Street, Cambridge, Massachusetts 02142, United States

2. Research & Development, Bristol Myers Squibb Company, Wallingford, Connecticut 06492, United States

3. Research & Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

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