2-Aminopyridines as Potent and Selective Na<sub>v</sub>1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model-Reference-Cited by-同舟云学术

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2-Aminopyridines as Potent and Selective Na_v1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model

Published:2024-05-24 Issue:6 Volume:15 Page:917-923
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Breslin Michael J.¹^ORCID,Schubert Jeffrey W.¹^ORCID,Wang Deping²,Huang Chienjung³,Clements Michelle K.³,Li Yuxing³,Zhou Xiaoping³,Vardigan Joshua D.³,Kraus Richard L.³,Santarelli Vincent P.³,Uslaner Jason M.⁴^ORCID,Coleman Paul J.¹,Stachel Shawn J.¹^ORCID

Affiliation:

1. Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, P.O. Box 4, West Point, Pennsylvania 19486, United States

2. Modeling and Informatics, Merck & Co., Inc., 770 Sumneytown Pike, P.O. Box 4, West Point, Pennsylvania 19486, United States

3. Neuroscience Biology Discovery, Merck & Co., Inc., 770 Sumneytown Pike, P.O. Box 4, West Point, Pennsylvania 19486, United States

4. Preclinical and Translational Medicine Discovery, Merck & Co., Inc., 770 Sumneytown Pike, P.O. Box 4, West Point, Pennsylvania 19486, United States

Funder

Merck

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.4c00103

Reference27 articles.

1. The Economic Costs of Pain in the United States

2. Opioid Complications and Side Effects

Voltage gated sodium channels as therapeutic targets for chronic pain

4. Voltage gated sodium channels as drug discovery targets

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