2-Aminopyridines as Potent and Selective Nav1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model

Author:

Breslin Michael J.1ORCID,Schubert Jeffrey W.1ORCID,Wang Deping2,Huang Chienjung3,Clements Michelle K.3,Li Yuxing3,Zhou Xiaoping3,Vardigan Joshua D.3,Kraus Richard L.3,Santarelli Vincent P.3,Uslaner Jason M.4ORCID,Coleman Paul J.1,Stachel Shawn J.1ORCID

Affiliation:

1. Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, P.O. Box 4, West Point, Pennsylvania 19486, United States

2. Modeling and Informatics, Merck & Co., Inc., 770 Sumneytown Pike, P.O. Box 4, West Point, Pennsylvania 19486, United States

3. Neuroscience Biology Discovery, Merck & Co., Inc., 770 Sumneytown Pike, P.O. Box 4, West Point, Pennsylvania 19486, United States

4. Preclinical and Translational Medicine Discovery, Merck & Co., Inc., 770 Sumneytown Pike, P.O. Box 4, West Point, Pennsylvania 19486, United States

Funder

Merck

Publisher

American Chemical Society (ACS)

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