Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding-Reference-Cited by-同舟云学术

Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding

Published:2024-05-29 Issue:6 Volume:15 Page:864-872
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Liang Jun¹^ORCID,Lambrecht Michael J.¹,Arenzana Teresita L.¹,Aubert-Nicol Samuel²,Bao Linda¹,Broccatelli Fabio¹,Cai Jianping³,Eidenschenk Celine¹,Everett Christine¹,Garner Thomas¹,Gruber Felix³,Haghshenas Pouyan²,Huestis Malcolm P.¹,Hsu Peter L.¹,Kou Ponien¹,Jakalian Araz²,Larouche-Gauthier Robin²^ORCID,Leclerc Jean-Philippe²,Leung Dennis H.¹,Martin Aaron¹,Murray Jeremy¹^ORCID,Prangley Madeleine¹,Rutz Sascha¹,Kakiuchi-Kiyota Satoko¹,Satz Alexander Lee³,Skelton Nicholas J.¹,Steffek Micah¹,Stoffler Daniel³,Sudhamsu Jawahar¹,Tan Sophia¹,Wang Jian⁴,Wang Shouliang⁴,Wang Qiuyue⁴,Wendorff Timothy J.¹,Wichert Moreno³,Yadav Arun²,Yu Christine¹,Wang Xiaojing¹

Affiliation:

1. Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. Paraza Pharma, 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1, Canada

3. Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland

4. WuXi AppTec Co., Ltd. 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai, 200131, P. R. China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.4c00068

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