SAR Study of 4,8-Disubstituted Pyrimido[5,4-<i>d</i>]pyrimidines Exhibiting Antitrypanosomal and Antileishmanial Activity-Reference-Cited by-同舟云学术

SAR Study of 4,8-Disubstituted Pyrimido[5,4-d]pyrimidines Exhibiting Antitrypanosomal and Antileishmanial Activity

Published:2024-08-22 Issue: Volume: Page:
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Lopes André¹²³^ORCID,Teixeira Sofia¹^ORCID,Santarém Nuno²³,Greco Alessandro⁴⁵⁶,Pagliaro Angela⁴⁵⁶,Keminer Oliver⁵⁶,Gul Sheraz⁵⁶^ORCID,Cordeiro-da-Silva Anabela²³^ORCID,Carvalho Maria Alice¹^ORCID

Affiliation:

1. Centre of Chemistry of University of Minho (CQUM), Campus de Gualtar, Braga, Portugal and Departamento de Química, Escola de Ciências da Universidade do Minho, Braga 4710-057, Portugal

2. Instituto de Investigação e Inovação em Saúde, Universidade do Porto and Institute for Molecular and Cell Biology, University of Porto, Porto 4150-180, Portugal

3. Departamento de Ciências Biológicas, Faculdade de Farmácia da Universidade do Porto (FFUP), Porto 4050-313, Portugal

4. Department of Pharmacy, University of Pisa, Via Bonanno 6, Pisa 56126, Italy

5. Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Hamburg 22525, Germany

6. Fraunhofer Cluster of Excellence for Immune-Mediated Diseases CIMD, Hamburg 22525, Germany

Funder

Erasmus+

European Cooperation in Science and Technology

Comiss?o de Coordena??o e Desenvolvimento Regional do Norte

European Social Fund Plus

Funda??o para a Ci?ncia e a Tecnologia

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.4c00277

Reference20 articles.

1. Leishmaniasis

2. World Health Organization: Leishmaniasis https://www.who.int/news-room/fact-sheets/detail/leishmaniasis (accessed 2024-02-11).

3. Human African trypanosomiasis

4. World Health Organization: Trypanosomiasis, human African (sleeping sickness) https://www.who.int/news-room/fact-sheets/detail/trypanosomiasis-human-african-(sleeping-sickness) (accessed 2024-04-21).

5. Oral fexinidazole for stage 1 or early stage 2 African Trypanosoma brucei gambiense trypanosomiasis: a prospective, multicentre, open-label, cohort study