Discovery of KLS-13019, a Cannabidiol-Derived Neuroprotective Agent, with Improved Potency, Safety, and Permeability-Reference-Cited by-同舟云学术

Discovery of KLS-13019, a Cannabidiol-Derived Neuroprotective Agent, with Improved Potency, Safety, and Permeability

Published:2016-02-15 Issue:4 Volume:7 Page:424-428
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Kinney William A.¹,McDonnell Mark E.¹,Zhong Hua Marlon²,Liu Chaomin²,Yang Lanyi²,Ling Wei²,Qian Tao²,Chen Yu²,Cai Zhijie²,Petkanas Dean¹,Brenneman Douglas E.¹

Affiliation:

1. KannaLife Sciences, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States

2. PharmaAdvance, Inc., 6 Dongsheng West Road, Building D1, Jiangyin, Jiangsu Province, P. R. China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.6b00009

Reference20 articles.

1. New assessment of hepatic encephalopathy

2. Mapping Metabolic Brain Activity in Three Models of Hepatic Encephalopathy

3. Acute and chronic ethanol increases reactive oxygen species generation and decreases viability in fresh, isolated rat hepatocytes

4. Cannabidiol and (-) 9-tetrahydrocannabinol are neuroprotective antioxidants

5. Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice

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