Discovery of a Potent, Selective, and Orally Available PI3Kδ Inhibitor for the Treatment of Inflammatory Diseases-Reference-Cited by-同舟云学术

Discovery of a Potent, Selective, and Orally Available PI3Kδ Inhibitor for the Treatment of Inflammatory Diseases

Published:2016-12-07 Issue:1 Volume:8 Page:118-123
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Erra Montse¹,Taltavull Joan¹,Gréco Angelique¹,Bernal Francisco Javier¹,Caturla Juan Francisco¹,Gràcia Jordi¹,Domínguez María¹,Sabaté Mar¹,Paris Stéphane¹,Soria Salomé¹,Hernández Begoña¹,Armengol Clara¹,Cabedo Judit¹,Bravo Mónica¹,Calama Elena¹,Miralpeix Montserrat¹,Lehner Martin D.¹

Affiliation:

1. Medicinal Chemistry and Screening, ‡Pharmacokinetics and Metabolism, §Systems Biology, and ∥Respiratory Therapeutic Area, Almirall R&D, Barcelona 08980, Spain

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.6b00438

Reference21 articles.

1. PI3K inhibitors in inflammation, autoimmunity and cancer

2. Selective inhibitors of phosphoinositide 3-kinase delta: modulators of B-cell function with potential for treating autoimmune inflammatory diseases and B-cell malignancies

3. Idelalisib in the management of lymphoma

4. Selective pharmacological inhibition of phosphoinositide 3-kinase p110delta opposes the progression of autoimmune diabetes in non-obese diabetic (NOD) mice

5. Randomized phase 1 study of the phosphatidylinositol 3-kinase δ inhibitor idelalisib in patients with allergic rhinitis

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